Oxford-based MitoRx Therapeutics has appointed Christine Charman, PhD as Chief Development Officer, David Richardson as Finance Director, and four new members to its Scientific Advisory Board. Dr Chapman was Senior Global Program Lead for Takeda’s Rare Diseases, Respiratory and Immunology and Neuroscience therapy areas. She also served as Program Lead supporting UK Vaccine and Antiviral Task Forces. David Richardson, BSc ACMA AMCT has over 30 years of experience including senior finance roles in AstraZeneca and Evotec. The board includes Prof Chas Bountra OBE (Pro-Vice Chancellor for Innovation at the University of Oxford), Prof Dame Kay Davies, CBE DBE FRS FMedSci (Dr Lee’s Professor of Anatomy Emeritus at the University of Oxford and co-director of the MDUK Oxford Neuromuscular Centre), Prof Laurent Servais (Director of the Specialised Translational Research Oxford Neuromuscular Group), and Dr Bernd C Schwahn, MD PhD FRCPCH (Honorary Clinical Senior Lecturer in Genomic Medicine). MitoRx aims to become a global leader in treating diseases caused by impaired mitochondrial function. The company is developing small molecules that are being pre-clinically tested in a mammalian model of muscular dystrophy. The company's compounds have been shown to suppress fibrosis in a murine chronic obstructive pulmonary disease model, reduce loss of function, and immune cell infiltration. Additionally, MitoRx has demonstrated the first complete restoration of movement in a dys-1 model of Duchenne muscular dystrophy (DMD), a genetic disorder characterized by progressive muscle degeneration and weakness. MitoRx indicates there are only a few weeks left for subscribers to make commitments to invest in MitoRx’s Advanced Subscription Agreement (ASA).
Oxford-based Harwell Campus has been selected by Moderna has chosen to host its Moderna Innovation and Technology Center (MITC). The MITC will include a research, development, and manufacturing facility, as well as a clinical biomarker laboratory. The facility will provide the UK public with access to cutting-edge mRNA vaccines for respiratory diseases, subject to regulatory approval. Construction will commence during 2023, and the facility is anticipated to become operational in 2025. It will create hundreds of jobs across Oxfordshire and the UK, and cement Harwell Campus as a national health tech hub for the pioneering research and development of mRNA and other nucleic acid therapeutics.
Bruntwood SciTech will invest £60 million into Manchester Science Park to create 131,000 sq ft of lab space. The new space will support life science businesses working in diagnostics, genomics, and precision medicine. The development will offer a range of CL2 labs with supporting office space from 2,500 sq ft to 22,000 sq ft floors. The BREEAM Excellent development will be environmentally friendly, aiming to achieve net zero carbon in construction and operation. The redevelopment of Greenheys will expand the existing life science cluster at Manchester Science Park, which is home to more than 150 businesses spanning biotech, precision medicine, diagnostics, digital health, cyber security, digital technology, medtech and light manufacturing. The new development is subject to planning approval by Manchester City Council.
The Francis Crick Institute is building an 11,800-square-foot life sciences laboratory on its roof. The lab, called Skylab, will be used for scientific partnerships, and MSD (NYSE: MRK) will be the first to lease it for three years. The aim is to maximise the exploitation of knowledge for societal benefit and the wider UK economy by providing additional laboratory space to expand partnership opportunities and increase the permeability of Crick science to the outside world. The partnership between Crick and MSD will address scientific problems or challenges brought forward by Crick researchers to understand age-related diseases, including the onset of neurodegeneration, by building models of Parkinson's disease using state-of-the-art stem cell technologies.
Abstract Securities has been granted detailed planning consent for the South Cambridge Science Centre (SCSC). The SCSC which will be a flexible laboratory for life sciences and biotechnology occupiers, offering much-needed new laboratory space in Cambridge. The SCSC will be built on a brownfield site in Sawston, around six miles from Cambridge City Centre and close to Babraham Research Park, Granta Park, and Unity Campus. The project will be delivered in two phases, with the first building of 140,000 sq. ft. ready for occupation in early 2025. Abstract is already in early discussions with a number of parties interested in the scheme.
London-based EyeBio has announced the appointment of senior executives. Anthony P. Adamis, M.D., has been appointed Chief Scientific Officer. Dr. Adamis co-founded EyeBio in 2021 and Eyetech in 2002. Prior to that, he served as Senior Vice President of Product Development and Development Innovation at Genentech. Loni Da Silva has been appointed Chief Regulatory Officer, bringing extensive ophthalmology regulatory leadership experience and led to Macugen’s approval, the first retinal drug; Frances Betts has been appointed Global Head, Clinical Operations, having recruited thousands of patients into more than 20 ophthalmology clinical trials; Mike Davies will serve as Chemistry, Manufacturing, and Control (CMC) Lead. He led protein sciences for the development of bispecific antibodies at F-Star Therapeutics; and Eric Ng, Ph.D., Senior Vice President, Biology, and Associate Professor in Ophthalmology at Harvard University.
London-based Vitrarka Therapeutics has appointed Dr Peter Simpson as Chief Scientific Officer and Board member. Dr Simpson is Honorary Professor at the University of Manchester and Chief Scientific Officer at Medicines Discovery Catapult. Vitrarka is developing RNAi therapies and non-viral delivery platform technology to promote the immune response normalise the tumour vasculature. Dr Simpson will collaborate in progressing the company’s EndoPore to the clinic.
Aberdeen-based Elasmogen has appointed Dr Jane Dancer as Chair of the Board. Dr Dances was Chief Business Officer at F-star, Vice President of Business Development at Cellzome, and Director of Business Development at Cambridge Antibody Technology. Currently, she is on the board of Spirea, PharmEnable, Macomics and NanoSyrinx. Elasmogen is developing a pipeline of novel targeting single domain biologics known as soloMERsTM for inflammatory disease and cancer.
Edinburgh-based Resolution Therapeutics has appointed Eli Gilsohn, PhD, MBA as Vice President, Intellectual Property. Prior to joining Resolution, he served Vice President, Intellectual Property at Tropic Biosciences, where he looked after the IP agreements required to form Tropic’s spin-out company, Laverock Therapeutics. The company is developing macrophage cell therapy to treat inflammatory organ disease. The company was founded based on a collaboration between Edinburgh’s Centre for Regenerative Medicine, the Scottish National Blood Transfusion Service, and Syncona Investment Management Limited.
Cambridge-based Cambridge Innovation Capital (CIC) has appointed Dipesh Patel, PhD as Operating Partner. Dr Patel will focus on technology investments. Prior to CIC, he was Chief Technology Officer at Arm, where he was a member of the Executive Committee at Arm since 2013. Prior to this, Dipesh served as President of the IoT Services Group.
London-based Claret Capital Partners has promoted Paul Bramley to Chief Financial Officer and Operational Partner.